Rabbit Secondary Antibodies
ABclonal Technology 647 Rabbit anti-Human CDA
This gene encodes an enzyme involved in pyrimidine salvaging The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine respectively It is one of several deaminases responsible for maintaining the cellular pyrimidine pool Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias
ABclonal Technology APC Rabbit anti-Human EGFR mAb
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily This protein is a receptor for members of the epidermal growth factor family EGFR is a cell surface protein that binds to epidermal growth factor Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation Mutations in this gene are associated with lung cancer
Jackson Immuno Research Labs Fluorescein (FITC)-AffiniPure Rabbit Anti-Human IgG F(ab')2 Fragment Specific
Fluorescein (FITC)-AffiniPure Rabbit Anti-Human IgG F(ab')2 Fragment Specific
ABclonal Technology 647 Rabbit anti-Human CD1d
This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells The human genome contains five CD1 family genes organized in a cluster on chromosome 1 The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail Two transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 594 Rabbit anti-Human IgG Fc
Predicted to enable antigen binding activity and immunoglobulin receptor binding activity Predicted to be involved in several processes including activation of immune response defense response to other organism and phagocytosis Predicted to act upstream of or within several processes including immunoglobulin mediated immune response positive regulation of hypersensitivity and positive regulation of phagocytosis Located in extracellular space
ABclonal Technology 594 Rabbit anti-Human MERTK
This gene is a member of the MER AXL TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains two Ig-like C2-type (immunoglobulin-like) domains and one tyrosine kinase domain Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP)
ABclonal Technology PE Rabbit anti-Human TLR1 mAb
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity TLRs are highly conserved from Drosophila to humans and share structural and functional similarities They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents and mediate the production of cytokines necessary for the development of effective immunity The various TLRs exhibit different patterns of expression This gene is ubiquitously expressed and at higher levels than other TLR genes Different length transcripts presumably resulting from use of alternative polyadenylation site and or from alternative splicing have been noted for this gene
ABclonal Technology 594 Rabbit anti-Human FATP1
Enables biotin transmembrane transporter activity efflux transmembrane transporter activity and long-chain fatty acid transporter activity Involved in several processes including carboxylic acid transmembrane transport glycerophospholipid biosynthetic process and lipid transport across blood-brain barrier Located in membrane Part of plasma membrane
ABclonal Technology 647 Rabbit anti-Human CD45
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth differentiation mitosis and oncogenic transformation This PTP contains an extracellular domain a single transmembrane segment and two tandem intracytoplasmic catalytic domains and thus is classified as a receptor type PTP This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling It functions through either direct interaction with components of the antigen receptor complexes or by activating various Src family kinases required for the antigen receptor signaling This PTP also suppresses JAK kinases and thus functions as a regulator of cytokine receptor signaling Alternatively spliced transcripts variants of this gene which encode distinct isoforms have been reported
Jackson Immuno Research Labs AMCA-AffiniPure Rabbit Anti-Human IgG (H+L)
AMCA-AffiniPure Rabbit Anti-Human IgG (H+L)
ABclonal Technology 610 Rabbit anti-Human IgD
IgD is the major antigen receptor isotype on the surface of most peripheral B-cells where it is coexpressed with IgM The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases
ABclonal Technology 647 Rabbit anti-Human PLZF
This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus This protein is located in the nucleus is involved in cell cycle progression and interacts with a histone deacetylase Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL) Alternate transcriptional splice variants have been characterized
ABclonal Technology PE Rabbit anti-Human CaSR mAb
The protein encoded by this gene is a plasma membrane G protein-coupled receptor that senses small changes in circulating calcium concentration The encoded protein couples this information to intracellular signaling pathways that modify parathyroid hormone secretion or renal cation handling and thus this protein plays an essential role in maintaining mineral ion homeostasis Mutations in this gene are a cause of familial hypocalciuric hypercalcemia neonatal severe hyperparathyroidism and autosomal dominant hypocalcemia
ABclonal Technology 700 Rabbit anti-Human CD58
This gene encodes a member of the immunoglobulin superfamily The encoded protein is a ligand of the T lymphocyte CD2 protein and functions in adhesion and activation of T lymphocytes The protein is localized to the plasma membrane Alternatively spliced transcript variants have been described
ABclonal Technology PE Rabbit anti-Human MRC2 mAb
This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer gliomas and metastatic bone disease